A VA of ≥20/50 was achieved in 7 of 49 patients (14%), but was <5/200 in 34 of 49 (69%) at last follow-up. Patients in the surgical wound–associated group were more likely to use topical steroids (20/22 vs 17/27 P = 0.024). Patients in the primary keratitis group were more likely to be male (22/27 vs 8/22 P = 0.001), have history of organic matter trauma (8/27 vs 1/22 ) P = 0.030), and have fungal etiology (21/27 vs 5/22 P<0.001). There were 27 patients in whom a primary infectious keratitis developed into endophthalmitis, and 22 patients in whom an infectious keratitis adjacent to a previous surgical wound progressed into endophthalmitis. Topical steroid use (37/49 ) was the most common associated factor identified in the current study, followed by previous surgery (30/49 ), corneal perforation (17/49 ), dry eye (15/49 ), relative immune compromise (10/49 ), organic matter trauma (9/49 ), and contact lens wear (3/49 ). Fungi (n = 26) were the most common responsible organism followed by gram-positive bacteria (n = 13) and gram-negative bacteria (n = 10). Only 49 eyes (0.5%) progressed to culture-proven endophthalmitis. ResultsĪ total of 9934 corneal cultures were performed for suspected infectious keratitis. Microbial isolates, treatment strategies, and visual acuity (VA) outcomes. Univariate analysis was performed to obtain P values described in the study. Ocular microbiology and medical records were reviewed on all patients with positive corneal and intraocular cultures over the period of the study. ParticipantsĪll patients treated for culture-proven keratitis and endophthalmitis between Januand December 31, 2009, at the Bascom Palmer Eye Institute. Nonrandomized, retrospective, consecutive case series. To describe the incidence, microbiology, associated factors, and clinical outcomes of patients with infectious keratitis progressing to endophthalmitis.
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